Milestones

MSNameWPLeadDate of DeliveryAchieved
1Samples collected2CNIO01-03-201629-02-2016
2Gene selection Panel 12CNIO01-03-201610-01-2016
3HAnDEL database up and running3ULEI01-09-201619-08-2016
4BCAC database up and running3UCAM01-09-201631-03-2016
5siRNA-based knockdown established4LUMC01-09-201601-05-2017
6Questionnaires for BOADICEA surveys completed5IC01-09-201615-05-2016
7Panel 1 sequencing completed2CNIO01-03-201705-04-2017
8Gene selection Panel 22CNIO01-03-2017
9Translation of PAHC in four languages completed5IC01-03-201731-08-2016
10In-silico analysis of sequence data of first gene panel completed3UCAM01-09-2017
11Scanning of naturally occurring alternative splice variants completed4SERMAS01-09-2017
12Assessment of complementation of deficient phenotype completed4LUMC01-09-2017
13RIgORouS completed4LUMC01-09-2017
14VUSplot available4LUMC01-09-2017
15Panel 2 sequencing completed2CNIO01-03-2018
16In-silico analysis of sequence data of second gene panel completed3UCAM01-09-2018
17Minigene constructs for 11 BC-HR genes available4CSIC01-09-2018
18E-learning steps 1 to 3 completed5UKK01-09-2018
19Patient decision aid completed5UKK01-09-2018
20Accrual of Cohort 1 for prospective observational study completed5UKK01-09-2018
21BOADICEA-PLUS completed3UCAM01-09-2019
22Analysis by the RIgORouS pipeline of 250 variants completed4LUMC01-09-2019
23Accrual of Cohort 2 for prospective observational study completed5IC01-09-2019
24Sequencing of BRIDGES panel completed2CNIO01-03-2020
25250 spliceogenic variants analyzed by minigene assay4SERMAS01-03-2020
26BOADICEAPLUS validated in prospective setting3UCAM01-09-2020
27Validated BOADICEA-PLUS disseminated via web interface3UCAM01-09-2020
28Statistical analyses of cohorts 1 and 2 completed3, 5UKK01-09-2020
29Genetic counseling guideline completed5UKK01-09-2020
LUMC= Leiden University Medical Centre, CNIO= Fundación Centro Nacional De Investigaciones Oncológicas Carlos III, LU= Lunds Universitet, IC= Institut Curie, SERMAS= Servicio Madrileno de Salud, UCAM= The Chancellor, Masters and Scholars of the University of Cambridge, and UKK= Universitaetsklinikum Koeln